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UniProt functional annotation for O96935 | ||
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| UniProt code: O96935. |
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| Organism: | |
Plasmodium falciparum (isolate FcB1 / Columbia). |
| Taxonomy: | |
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania). |
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| Function: | |
Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC. {ECO:0000269|PubMed:12166515, ECO:0000269|PubMed:19196988}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:19196988, ECO:0000269|PubMed:21366301}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:19196988, ECO:0000269|PubMed:21366301}; |
| Activity regulation: | |
Inhibited by 1,10-phenanthroline, EDTA and bestatin. Activity is not affected by phosphoramidin, PMSF, leupeptin, iodoacetamide or pepstatin. {ECO:0000269|PubMed:12166515, ECO:0000269|PubMed:19196988}. |
| Biophysicochemical properties: | |
pH dependence: Optimum pH is 7.4. Active from pH 5.8 to 8.6, with less than 20% of normal activity at pH 6.0. {ECO:0000269|PubMed:19196988}; |
| Subcellular location: | |
Cytoplasm. Cytoplasm, cytosol. |
| Developmental stage: | |
Expressed in all erythrocytic stages. {ECO:0000269|PubMed:19196988, ECO:0000269|PubMed:9879894}. |
| Ptm: | |
The 120 kDa precursor is cleaved in vitro into 96 kDa and 68 kDa forms. |
| Similarity: | |
Belongs to the peptidase M1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.