|
|
||
|
|
|
|
|
UniProt functional annotation for P15907 | ||
|
|
|
|
|
|
||
| UniProt code: P15907. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Transfers sialic acid from CMP-sialic acid to galactose- containing acceptor substrates. {ECO:0000269|PubMed:21081508, ECO:0000269|PubMed:23999306}. |
|
||
| Catalytic activity: | |
Reaction=a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N- acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+); Xref=Rhea:RHEA:52104, ChEBI:CHEBI:15378, ChEBI:CHEBI:28034, ChEBI:CHEBI:57812, ChEBI:CHEBI:60377, ChEBI:CHEBI:136398; EC=2.4.99.1; Evidence={ECO:0000269|PubMed:21081508, ECO:0000269|PubMed:23999306}; |
| Activity regulation: | |
Inhibited by CTP. {ECO:0000269|PubMed:23999306}. |
| Biophysicochemical properties: | |
Kinetic parameters: KM=530 uM for CMP-NeuAc {ECO:0000269|PubMed:21081508}; Vmax=1.074 pmol/min/ug enzyme {ECO:0000269|PubMed:21081508}; |
| Pathway: | |
Protein modification; protein glycosylation. |
| Subunit: | |
Monomer and homodimer. {ECO:0000269|PubMed:20378551}. |
| Subcellular location: | |
Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:20378551}; Single-pass type II membrane protein {ECO:0000305}. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid. |
| Ptm: | |
The soluble form derives from the membrane form by proteolytic processing. {ECO:0000250|UniProtKB:P13721}. |
| Ptm: | |
The HB-6, CDW75, and CD76 differentiation antigens are cell- surface carbohydrate determinants generated by this enzyme. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:23999306}. |
| Similarity: | |
Belongs to the glycosyltransferase 29 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.