UniProt functional annotation for P55210



	UniProt functional annotation for P55210

UniProt code: P55210.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP- ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

Catalytic activity: Reaction=Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-.; EC=3.4.22.60;

Activity regulation: Inhibited by isatin sulfonamides.

Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Interacts with ATXN3 (short isoform 1) (PubMed:30455355). Interacts with HSPA5 (PubMed:26045166). {ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:30455355}.

Subcellular location: Cytoplasm.

Tissue specificity: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.

Ptm: Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur. {ECO:0000269|PubMed:8755496}.

Miscellaneous: [Isoform Beta]: Lacks enzymatic activity. {ECO:0000305}.

Miscellaneous: [Isoform Alpha']: What we call isoform Alpha' is also known as Beta. {ECO:0000305|PubMed:9070923}.

Similarity: Belongs to the peptidase C14A family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP- ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.


Catalytic activity:		Reaction=Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-\|-.; EC=3.4.22.60;
Activity regulation:		Inhibited by isatin sulfonamides.
Subunit:		Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Interacts with ATXN3 (short isoform 1) (PubMed:30455355). Interacts with HSPA5 (PubMed:26045166). {ECO:0000269\|PubMed:11701129, ECO:0000269\|PubMed:15200957, ECO:0000269\|PubMed:26045166, ECO:0000269\|PubMed:30455355}.
Subcellular location:		Cytoplasm.
Tissue specificity:		Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
Ptm:		Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur. {ECO:0000269\|PubMed:8755496}.
Miscellaneous:		[Isoform Beta]: Lacks enzymatic activity. {ECO:0000305}.
Miscellaneous:		[Isoform Alpha']: What we call isoform Alpha' is also known as Beta. {ECO:0000305\|PubMed:9070923}.
Similarity:		Belongs to the peptidase C14A family. {ECO:0000305}.