|
|
||
|
|
|
|
|
UniProt functional annotation for P00178 | ||
|
|
|
|
|
|
||
| UniProt code: P00178. |
|
||
| Organism: | |
Oryctolagus cuniculus (Rabbit). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus. |
|
||
|
||
| Function: | |
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin. |
|
||
| Catalytic activity: | |
Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; |
| Cofactor: | |
Name=heme; Xref=ChEBI:CHEBI:30413; |
| Subcellular location: | |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Induction: | |
By phenobarbital. |
| Polymorphism: | |
Types B0 and B1 are probably allelic variants. |
| Similarity: | |
Belongs to the cytochrome P450 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.