PDBsum entry 4jgd

Oxidoreductase

PDB id: 4jgd

Contents

Protein chain

364 a.a.

Ligands

FMN

ORO

DET

SO4 ×9

4JG

Waters ×247

PDB id:

4jgd

Name:

Oxidoreductase

Title:

Crystal structure of human dihydroorotate dehydrogenase (dhodh) with dh03a016

Structure:

Dihydroorotate dehydrogenase (quinone), mitochondrial. Chain: a. Synonym: dhodehase, dihydroorotate oxidase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dhodh. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.05Å R-factor: 0.160 R-free: 0.175

Authors:

L.Zhu,J.Zhu,X.Ren,H.Li

Key ref:

L.Zhu et al. Crystal structure of human dihydroorotate dehydrogena (dhodh) with dh03a016. To be published, .

Date:

01-Mar-13 Release date: 05-Mar-14

Protein chain

Q02127  (PYRD_HUMAN) -  Dihydroorotate dehydrogenase (quinone), mitochondrial from Homo sapiens

Seq: 395 a.a.

Struc: 364 a.a.

Enzyme reactions

• Enzyme class: E.C.1.3.5.2 - dihydroorotate dehydrogenase (quinone).
• Reaction: (S)-dihydroorotate + a quinone = orotate + a quinol

(S)-dihydroorotate (Bound ligand (Het Group name = ORO) corresponds exactly) + quinone (Bound ligand (Het Group name = DET) matches with 43.75% similarity) = orotate + quinol

• Cofactor: FMN

FMN (Bound ligand (Het Group name = FMN) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site