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UniProt functional annotation for P04818 | ||
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| UniProt code: P04818. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000269|PubMed:21876188}. |
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| Catalytic activity: | |
Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP; Xref=Rhea:RHEA:12104, ChEBI:CHEBI:15636, ChEBI:CHEBI:57451, ChEBI:CHEBI:63528, ChEBI:CHEBI:246422; EC=2.1.1.45; |
| Pathway: | |
Pyrimidine metabolism; dTTP biosynthesis. |
| Subunit: | |
Homodimer. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:21876188}. Cytoplasm {ECO:0000269|PubMed:21876188}. Mitochondrion {ECO:0000269|PubMed:21876188}. Mitochondrion matrix {ECO:0000269|PubMed:21876188}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}. |
| Miscellaneous: | |
[Isoform 2]: Expressed both in normal and cancerous tissues. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 3]: Expressed only in cancerous tissues. {ECO:0000305}. |
| Similarity: | |
Belongs to the thymidylate synthase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.