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UniProt functional annotation for O54440 | ||
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| UniProt code: O54440. |
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| Organism: | |
Pseudomonas aeruginosa. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. |
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| Function: | |
Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. {ECO:0000256|PIRNR:PIRNR000447}. |
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| Catalytic activity: | |
Reaction=(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)- octadecenoyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:55040, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:10800, Rhea:RHEA-COMP:14074, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:83989, ChEBI:CHEBI:138538; EC=2.3.1.179; Evidence={ECO:0000256|PIRNR:PIRNR000447}; |
| Catalytic activity: | |
Reaction=a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]; Xref=Rhea:RHEA:22836, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9916, Rhea:RHEA-COMP:14125, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:64479, ChEBI:CHEBI:78449, ChEBI:CHEBI:78776, ChEBI:CHEBI:138651; Evidence={ECO:0000256|PIRNR:PIRNR000447}; |
| Pathway: | |
Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}. |
| Pathway: | |
Lipid metabolism; fatty acid biosynthesis. {ECO:0000256|ARBA:ARBA00005194, ECO:0000256|PIRNR:PIRNR000447}. |
| Similarity: | |
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. {ECO:0000256|ARBA:ARBA00008467, ECO:0000256|PIRNR:PIRNR000447, ECO:0000256|RuleBase:RU003694}. |
Annotations taken from UniProtKB at the EBI.