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UniProt functional annotation for P9WPF3 | ||
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| UniProt code: P9WPF3. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Involved in the biosynthesis of methyl-branched alkylpyrones (PubMed:23615910). Pks11 catalyzes the extension of medium- and long- chain aliphatic acyl-CoA substrates by using malonyl-CoA and methylmalonyl-CoA as extender molecules to synthesize polyketide products (PubMed:12941968, PubMed:23615910). Palmitoyl-CoA or a similar long chain fatty acid derivative is the likely substrate in vivo (PubMed:23615910). {ECO:0000269|PubMed:12941968, ECO:0000269|PubMed:23615910}. |
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| Catalytic activity: | |
Reaction=2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA = 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA; Xref=Rhea:RHEA:44296, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57384, ChEBI:CHEBI:59916, ChEBI:CHEBI:84253; Evidence={ECO:0000269|PubMed:23615910}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44297; Evidence={ECO:0000269|PubMed:23615910}; |
| Catalytic activity: | |
Reaction=2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA = 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA; Xref=Rhea:RHEA:44300, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:57394, ChEBI:CHEBI:59916, ChEBI:CHEBI:84255; Evidence={ECO:0000269|PubMed:23615910}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44301; Evidence={ECO:0000269|PubMed:23615910}; |
| Catalytic activity: | |
Reaction=2 H(+) + hexanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6- pentylpyran-2-one + 2 CO2 + 3 CoA; Xref=Rhea:RHEA:43452, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:62620, ChEBI:CHEBI:66958; Evidence={ECO:0000269|PubMed:12941968}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43453; Evidence={ECO:0000269|PubMed:12941968}; |
| Catalytic activity: | |
Reaction=dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6- undecylpyran-2-one + 2 CO2 + 3 CoA; Xref=Rhea:RHEA:43460, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:57384, ChEBI:CHEBI:84149; Evidence={ECO:0000269|PubMed:12941968}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43461; Evidence={ECO:0000269|PubMed:12941968}; |
| Catalytic activity: | |
Reaction=dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2- oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:43368, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375, ChEBI:CHEBI:57384, ChEBI:CHEBI:84150; Evidence={ECO:0000269|PubMed:12941968}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43369; Evidence={ECO:0000269|PubMed:12941968}; |
| Pathway: | |
Lipid metabolism; fatty acid biosynthesis. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:23615910}. |
| Similarity: | |
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.