PDBsum entry 4j9c

Transferase/unknown function

PDB id: 4j9c

Contents

Protein chains

58 a.a.

11 a.a.

Ligands

PGE

PEG

Waters ×80

References listed in PDB file

Key reference

Title

Crystal structure of the abl-Sh3 domain h59q-N96t mut complexed with the designed high-Affinity peptide lig

Author

A.Camara-Artigas.

Ref.

TO BE PUBLISHED ...

Secondary reference #1

Title

Crystallization by capillary counter-Diffusion and structure determination of the n114a mutant of the sh3 domain of abl tyrosine kinase complexed with a high-Affinity peptide ligand.

Authors

A.Cámara-Artigas, A.Palencia, J.C.Martínez, I.Luque, J.A.Gavira, J.M.García-Ruiz.

Ref.

Acta Crystallogr D Biol Crystallogr, 2007, 63, 646-652. [DOI no: 10.1107/S0907444907011109]

PubMed id

17452790

Figure 2.
Figure 2 Overall fold of the N114A mutant of the SH3 domain of Ab1 in complex with the p41 decapeptide. Residues in the SH3 domain-binding site are shown as green sticks. The decapeptide p41 is shown as yellow sticks. The proline residues interacting with the three hydrophobic pockets (pocket 1, Tyr70/Tyr115; pocket 2, Tyr115/Phe72/Trp99; pocket 3, Trp99/Trp110/Asn78) in the SH3 domain are indicated.

Figure 5.
Figure 5 Superposition of the N114 Abl-SH3-p41 complex (cyan) and the Abl tyrosine kinase structure (PDB code 1opk ; pale green). The SH2-kinase linker implicated in regulation of the kinase activity is coloured orange. Relevant water molecules are shown as red spheres.

The above figures are reproduced from the cited reference with permission from the IUCr

Secondary reference #2

Title

Role of interfacial water molecules in proline-Rich ligand recognition by the src homology 3 domain of abl.

Authors

A.Palencia, A.Camara-Artigas, M.T.Pisabarro, J.C.Martinez, I.Luque.

Ref.

J Biol Chem, 2010, 285, 2823-2833.

PubMed id

19906645