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UniProt functional annotation for P50503 | ||
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| UniProt code: P50503. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. {ECO:0000269|PubMed:7585962}. |
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| Subunit: | |
Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90. Interacts (via the C-terminus 302- 318 AA) with GRK5 (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm. |
| Similarity: | |
Belongs to the FAM10 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.