PDBsum entry 4j4h

Oxidoreductase

PDB id: 4j4h

Contents

Protein chains

259 a.a.

Ligands

NAI ×4

1J1 ×4

Metals

_MG ×4

_NA ×4

Waters ×558

References listed in PDB file

Key reference

• Title: Structure and reaction mechanism of pyrrolysine synthase (pyld).
• Authors: F.Quitterer, P.Beck, A.Bacher, M.Groll.
• Ref.: Angew Chem Int Ed Engl, 2013, 52, 7033-7037. [DOI no: 10.1002/anie.201301164]
• PubMed id: 23720358

Abstract

The final step in the biosynthesis of the 22nd genetically encoded amino acid, pyrrolysine, is catalyzed by PylD, a structurally and mechanistically unique dehydrogenase. This catalyzed reaction includes an induced-fit mechanism achieved by major structural rearrangements of the N-terminal helix upon substrate binding. Different steps of the reaction trajectory are visualized by complex structures of PylD with substrate and product.