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UniProt functional annotation for P56273 | ||
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| UniProt code: P56273. |
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| Organism: | |
Xenopus laevis (African clawed frog). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus. |
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| Function: | |
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q00987}. |
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| Catalytic activity: | |
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000250|UniProtKB:Q00987}; |
| Subcellular location: | |
Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P23804}. Cytoplasm {ECO:0000250|UniProtKB:P23804}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P23804}. Nucleus {ECO:0000250|UniProtKB:Q00987}. |
| Developmental stage: | |
Expression increases from oocyte stage I/II to reach its maximum in oocyte stage v/vi in unfertilized eggs, and then progressively decreases to become undetectable at the gastrula stage. |
| Similarity: | |
Belongs to the MDM2/MDM4 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.