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UniProt functional annotation for P48546 | ||
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| UniProt code: P48546. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
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| Subunit: | |
May form homodimers and heterodimers with GLP1R. {ECO:0000269|PubMed:17715056, ECO:0000269|PubMed:22412906}. |
| Subcellular location: | |
Cell membrane; Multi-pass membrane protein. |
| Ptm: | |
N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER. {ECO:0000269|PubMed:22412906}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 2 family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CAA57426.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.