UniProt functional annotation for P02931



	UniProt functional annotation for P02931

UniProt code: P02931.

Organism: Escherichia coli (strain K12).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: Forms pores that allow passive diffusion of small molecules across the outer membrane. {ECO:0000305|PubMed:19721064}.

Function: (Microbial infection) It is also a receptor for the bacteriophage T2. Is the major receptor for colicin E5 (Probable). {ECO:0000305|PubMed:27723824}.

Function: (Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536; polymorphisms in extracellular loops 4 and 5 of OmpC confer susceptibility to CdiA- EC536-mediated toxicity. {ECO:0000269|PubMed:27723824}.

Subunit: Homotrimer (PubMed:2464593, PubMed:16079137). Forms mixed heterotrimers with OmpC and with PhoE; other mixed heterotrimers are also probable (PubMed:2464593). {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:2464593}.

Subcellular location: Cell outer membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:2464593}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}.

Induction: By growth in low osmolarity conditions (low sugar or salt); activated at low osmolarity by OmpR, repressed at high osmolarity by OmpR (at protein level) (PubMed:3010044, PubMed:2464593). Levels of OmpF protein decrease in a lon/ycgE double disruption (at protein level) (PubMed:19721064). {ECO:0000269|PubMed:19721064, ECO:0000269|PubMed:2464593, ECO:0000269|PubMed:3010044}.

Disruption phenotype: Leads to decreased susceptibility to a number of hydrophilic antibiotics including ampicillin, cefoxitin and tetracycline (PubMed:19721064). Deletion of ompF confers resistance to colicin E5 (PubMed:27723824). {ECO:0000269|PubMed:19721064, ECO:0000269|PubMed:27723824}.

Similarity: Belongs to the Gram-negative porin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli (strain K12).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		Forms pores that allow passive diffusion of small molecules across the outer membrane. {ECO:0000305\|PubMed:19721064}.



Function:		(Microbial infection) It is also a receptor for the bacteriophage T2. Is the major receptor for colicin E5 (Probable). {ECO:0000305\|PubMed:27723824}.



Function:		(Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536; polymorphisms in extracellular loops 4 and 5 of OmpC confer susceptibility to CdiA- EC536-mediated toxicity. {ECO:0000269\|PubMed:27723824}.


Subunit:		Homotrimer (PubMed:2464593, PubMed:16079137). Forms mixed heterotrimers with OmpC and with PhoE; other mixed heterotrimers are also probable (PubMed:2464593). {ECO:0000269\|PubMed:16079137, ECO:0000269\|PubMed:2464593}.
Subcellular location:		Cell outer membrane {ECO:0000269\|PubMed:16079137, ECO:0000269\|PubMed:2464593}; Multi-pass membrane protein {ECO:0000269\|PubMed:16079137}.
Induction:		By growth in low osmolarity conditions (low sugar or salt); activated at low osmolarity by OmpR, repressed at high osmolarity by OmpR (at protein level) (PubMed:3010044, PubMed:2464593). Levels of OmpF protein decrease in a lon/ycgE double disruption (at protein level) (PubMed:19721064). {ECO:0000269\|PubMed:19721064, ECO:0000269\|PubMed:2464593, ECO:0000269\|PubMed:3010044}.
Disruption phenotype:		Leads to decreased susceptibility to a number of hydrophilic antibiotics including ampicillin, cefoxitin and tetracycline (PubMed:19721064). Deletion of ompF confers resistance to colicin E5 (PubMed:27723824). {ECO:0000269\|PubMed:19721064, ECO:0000269\|PubMed:27723824}.
Similarity:		Belongs to the Gram-negative porin family. {ECO:0000305}.