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UniProt functional annotation for P00447 | ||
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| UniProt code: P00447. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. |
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| Catalytic activity: | |
Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1; |
| Cofactor: | |
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250}; |
| Subunit: | |
Homotetramer. |
| Subcellular location: | |
Mitochondrion matrix. |
| Miscellaneous: | |
Present with 10900 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the iron/manganese superoxide dismutase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.