PDBsum entry 4ev5

Oxidoreductase

PDB id: 4ev5

Contents

Protein chains

(+ 0 more) 654 a.a.

Ligands

GOL ×30

PEO ×4

ABN ×6

Metals

_CU ×6

Waters ×3041

PDB id:

4ev5

Name:

Oxidoreductase

Title:

Crystal structure of copper amine oxidase-1 from hansenula polymorpha in complex with benzylamine

Structure:

Peroxisomal primary amine oxidase. Chain: a, b, c, d, e, f. Synonym: copper amine oxidase, methylamine oxidase. Engineered: yes

Source:

Ogataea angusta. Yeast. Organism_taxid: 870730. Gene: amo. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932

Resolution:

2.25Å R-factor: 0.172 R-free: 0.230

Authors:

V.J.Klema,C.J.Solheid,C.M.Wilmot

Key ref:

V.J.Klema et al. Crystal structure of copper amine oxidase-1 from hans polymorpha in complex with benzylamine. To be published, .

Date:

25-Apr-12 Release date: 13-Mar-13

Protein chains

P12807  (AMO_PICAN) -  Peroxisomal primary amine oxidase from Pichia angusta

Seq: 692 a.a.

Struc: 654 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.1.4.3.21 - primary-amine oxidase.
• Reaction: a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4⁺

primary methyl amine + O2 + H2O (Bound ligand (Het Group name = PEO) corresponds exactly) = aldehyde + H2O2 + NH4(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site