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UniProt functional annotation for Q2FIA5 | ||
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| UniProt code: Q2FIA5. |
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| Organism: | |
Staphylococcus aureus (strain USA300). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
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| Function: | |
Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide. {ECO:0000255|HAMAP-Rule:MF_01608}. |
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| Catalytic activity: | |
Reaction=2 CoA + NADP(+) = CoA-disulfide + H(+) + NADPH; Xref=Rhea:RHEA:14705, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62209; EC=1.8.1.14; Evidence={ECO:0000255|HAMAP-Rule:MF_01608}; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000255|HAMAP-Rule:MF_01608}; Note=Binds 1 FAD per subunit. {ECO:0000255|HAMAP-Rule:MF_01608}; |
| Subunit: | |
Homodimer. {ECO:0000255|HAMAP-Rule:MF_01608}. |
| Domain: | |
Contains 2 FAD binding domains and a single NADPH binding domain. {ECO:0000255|HAMAP-Rule:MF_01608}. |
| Miscellaneous: | |
Reduction of disulfides occurs by a thiol-disulfide exchange reaction, but involves only a single catalytic cysteine residue that forms a stable mixed disulfide with CoA during catalysis. {ECO:0000255|HAMAP-Rule:MF_01608}. |
| Similarity: | |
Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000255|HAMAP-Rule:MF_01608}. |
Annotations taken from UniProtKB at the EBI.