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UniProt functional annotation for Q38EJ2 | ||
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| UniProt code: Q38EJ2. |
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| Organism: | |
Trypanosoma brucei brucei (strain 927/4 GUTat10.1). |
| Taxonomy: | |
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Trypanosoma. |
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| Catalytic activity: | |
Reaction=(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4- carboxamido]succinate = 5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide + fumarate; Xref=Rhea:RHEA:23920, ChEBI:CHEBI:29806, ChEBI:CHEBI:58443, ChEBI:CHEBI:58475; EC=4.3.2.2; Evidence={ECO:0000256|ARBA:ARBA00000598, ECO:0000256|RuleBase:RU361172}; |
| Catalytic activity: | |
Reaction=N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate; Xref=Rhea:RHEA:16853, ChEBI:CHEBI:29806, ChEBI:CHEBI:57567, ChEBI:CHEBI:456215; EC=4.3.2.2; Evidence={ECO:0000256|ARBA:ARBA00000811, ECO:0000256|RuleBase:RU361172}; |
| Pathway: | |
Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2. {ECO:0000256|ARBA:ARBA00004734, ECO:0000256|RuleBase:RU361172}. |
| Pathway: | |
Purine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2. {ECO:0000256|ARBA:ARBA00004706, ECO:0000256|RuleBase:RU361172}. |
| Similarity: | |
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. {ECO:0000256|ARBA:ARBA00008273, ECO:0000256|RuleBase:RU361172}. |
Annotations taken from UniProtKB at the EBI.