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PDBsum entry 4ea3
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protein ligands Protein-protein interface(s) links
Signaling protein PDB id
4ea3

 

 

 

 

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Contents
Protein chains
278 a.a.
376 a.a.
Ligands
0NN ×2
OLB
OLA
OLC
Waters ×8
PDB id:
4ea3
Name: Signaling protein
Title: Structure of the n/ofq opioid receptor in complex with a peptide mimetic
Structure: Fusion protein of nociceptin receptor and cytochrome b562. Chain: a, b. Synonym: op4, kor-3, orl1, nociceptin/orphanin fq receptor, cytochrome b-562. Engineered: yes. Mutation: yes
Source: Escherichia coli, homo sapiens. Organism_taxid: 562, 9606. Gene: oor, oprl1, orl1, cybc. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Resolution:
3.01Å     R-factor:   0.251     R-free:   0.288
Authors: A.A.Thompson,W.Liu,E.Chun,V.Katritch,H.Wu,E.Vardy,X.P.Huang, C.Trapella,R.Guerrini,G.Calo,B.L.Roth,V.Cherezov,R.C.Stevens,Gpcr Network (Gpcr)
Key ref: A.A.Thompson et al. (2012). Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature, 485, 395-399. PubMed id: 22596163
Date:
22-Mar-12     Release date:   25-Apr-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli
Seq:
Struc: 		128 a.a.
278 a.a.*
Protein chain
Pfam   ArchSchema ?
P41146  (OPRX_HUMAN) -  Nociceptin receptor from Homo sapiens
Seq:
Struc: 		370 a.a.
278 a.a.
Protein chain
Pfam   ArchSchema ?
P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli
Seq:
Struc: 		128 a.a.
376 a.a.*
Protein chain
Pfam   ArchSchema ?
P41146  (OPRX_HUMAN) -  Nociceptin receptor from Homo sapiens
Seq:
Struc: 		370 a.a.
376 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 138 residue positions (black crosses)

 

 
Nature 485:395-399 (2012)
PubMed id: 22596163  
 
 
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.
A.A.Thompson, W.Liu, E.Chun, V.Katritch, H.Wu, E.Vardy, X.P.Huang, C.Trapella, R.Guerrini, G.Calo, B.L.Roth, V.Cherezov, R.C.Stevens.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23407534 A.J.Venkatakrishnan, X.Deupi, G.Lebon, C.G.Tate, G.F.Schertler, and M.M.Babu (2013).
Molecular signatures of G-protein-coupled receptors.
  Nature, 494, 185-194.  
23051750 F.Hausch, and F.Holsboer (2012).
Structural biology: Snapshot of an activated peptide receptor.
  Nature, 490, 492-493.  
23051748 J.F.White, N.Noinaj, Y.Shibata, J.Love, B.Kloss, F.Xu, J.Gvozdenovic-Jeremic, P.Shah, J.Shiloach, C.G.Tate, and R.Grisshammer (2012).
Structure of the agonist-bound neurotensin receptor.
  Nature, 490, 508-513.
PDB code: 4grv
23237917 R.C.Stevens, V.Cherezov, V.Katritch, R.Abagyan, P.Kuhn, H.Rosen, and K.Wüthrich (2012).
The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.
  Nat Rev Drug Discov, 12, 25-34.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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