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UniProt functional annotation for P50743 | ||
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| UniProt code: P50743. |
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| Organism: | |
Bacillus subtilis (strain 168). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. |
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| Function: | |
GTPase that plays an essential role in the late steps of ribosome biogenesis. {ECO:0000269|PubMed:16997968}. |
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| Subunit: | |
Cofractionates with the 70S ribosome; association is stabilized by the non-hydrolyzable GTP analog GMPPNP, and inhibited by GTP or GDP. |
| Disruption phenotype: | |
Essential for growth, it cannot be disrupted. Depletion experiments show that cells become longer and abnormally curved, with nucleoid condensation. Cells have many fewer 70S ribosomes; the large ribosomal subunit is 45S and is missing proteins L16, L27, L36 and interacts with 2 large non-ribosomal proteins. {ECO:0000269|PubMed:12427945}. |
| Miscellaneous: | |
Estimated to be present at 7000 copies per cell. |
| Similarity: | |
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=U32164; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.