PDBsum entry 4d73

Oxidoreductase

PDB id: 4d73

Contents

Protein chains

172 a.a.

170 a.a.

Waters ×234

PDB id:

4d73

Name:

Oxidoreductase

Title:

X-ray structure of a peroxiredoxin

Structure:

1-cys peroxiredoxin. Chain: a. Engineered: yes. Mutation: yes. 1-cys peroxiredoxin. Chain: b. Engineered: yes. Mutation: yes

Source:

Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.80Å R-factor: 0.154 R-free: 0.195

Authors:

V.Staudacher,C.F.Djuika,J.Koduka,S.Schlossarek,J.Kopp,M.Buechler, M.Lanzer,M.Deponte

Key ref:

V.Staudacher et al. (2015). Plasmodium falciparum antioxidant protein reveals a novel mechanism for balancing turnover and inactivation of peroxiredoxins. Free Radic Biol Med, 85, 228-236. PubMed id: 25952724 DOI: 10.1016/j.freeradbiomed.2015.04.030

Date:

19-Nov-14 Release date: 13-May-15

Protein chain

Q5MYR6  (Q5MYR6_PLAF7) -  1-cys peroxiredoxin from Plasmodium falciparum (isolate 3D7)

Seq: 240 a.a.

Struc: 172 a.a.*

Protein chain

Q5MYR6  (Q5MYR6_PLAF7) -  1-cys peroxiredoxin from Plasmodium falciparum (isolate 3D7)

Seq: 240 a.a.

Struc: 170 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.1.11.1.15 - Transferred entry: 1.11.1.24, 1.11.1.25, 1.11.1.26, 1.11.1.27, 1.11.1.28
• Pathway: Peroxiredoxin
• Reaction: 2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1016/j.freeradbiomed.2015.04.030

Free Radic Biol Med 85:228-236 (2015)

PubMed id: 25952724

Plasmodium falciparum antioxidant protein reveals a novel mechanism for balancing turnover and inactivation of peroxiredoxins.

V.Staudacher, C.F.Djuika, J.Koduka, S.Schlossarek, J.Kopp, M.Büchler, M.Lanzer, M.Deponte.

ABSTRACT

No abstract given.