|
|
||
|
|
|
|
|
UniProt functional annotation for P0CH62 | ||
|
|
|
|
|
|
||
| UniProt code: P0CH62. |
|
||
| Organism: | |
Azoarcus sp. |
| Taxonomy: | |
Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales; Zoogloeaceae; Azoarcus; unclassified Azoarcus. |
|
||
|
||
| Function: | |
Catalyzes the ring-opening cleavage of the alicyclic alcohol cyclohexane-1,2-dione. {ECO:0000269|Ref.1}. |
|
||
| Catalytic activity: | |
Reaction=cyclohexan-1,2-dione + H2O = 6-oxohexanoate + H(+); Xref=Rhea:RHEA:26514, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18322, ChEBI:CHEBI:41674; EC=3.7.1.11; Evidence={ECO:0000269|Ref.1}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|Ref.1}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000269|Ref.1}; |
| Cofactor: | |
Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000269|Ref.1}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000269|Ref.1}; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000269|Ref.1}; Note=Binds 1 FAD per subunit. {ECO:0000269|Ref.1}; |
| Biophysicochemical properties: | |
Kinetic parameters: KM=12.3 uM for cyclohexane-1,2-dione {ECO:0000269|Ref.1}; pH dependence: Optimum pH is 8. {ECO:0000269|Ref.1}; |
| Subunit: | |
Homodimer. {ECO:0000269|Ref.1, ECO:0000269|Ref.2}. |
| Similarity: | |
Belongs to the TPP enzyme family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.