UniProt functional annotation for P0DKH5



	UniProt functional annotation for P0DKH5

UniProt code: P0DKH5.

Organism: Arabidopsis thaliana (Mouse-ear cress).

Taxonomy: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.

Function: Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. Acts also as a disease resistance protein involved in resistance to fungal and bacterial pathogens, including R.solanacearum, P.syringae pv. tomato and C.higginsianum. Heterodimerization with RPS4 is required to form a functional complex to recognize AvrRps4 and PopP2 (PubMed:24744375). Contributes to temperature-conditioned RPS4 auto- immunity (PubMed:24146667). {ECO:0000269|PubMed:10571887, ECO:0000269|PubMed:11842188, ECO:0000269|PubMed:19519800, ECO:0000269|PubMed:24146667, ECO:0000269|PubMed:24744375, ECO:0000305}.

Subunit: Interacts with PopP2, a R.solanacearum type III effector (PubMed:12788974). Interacts with RPS4 (PubMed:24744375). {ECO:0000269|PubMed:12788974, ECO:0000269|PubMed:24744375}.

Subcellular location: Nucleus {ECO:0000269|PubMed:12788974}. Cytoplasm {ECO:0000305|PubMed:12788974}. Note=The nuclear localization is only detected upon interaction with PopP2. {ECO:0000269|PubMed:12788974}.

Domain: The TIR does not cause cell death, but can suppress RPS4 TIR domain-induced cell death (PubMed:24744375). The TIR domain is involved in homo- and heterodimerization, but other domains also contribute to the interaction (PubMed:24744375). {ECO:0000269|PubMed:24744375}.

Miscellaneous: Ecotypes susceptible to C.higginsianum or R.solanacearum, such as cv. Columbia, contain a protein with a premature stop codon, while the longer allele found in cv. Nd-1, cv. Wassilewskija or cv. RLD confers resistance. {ECO:0000269|PubMed:19519800}.

Miscellaneous: [Isoform 2]: May be due to intron retention. {ECO:0000305}.

Similarity: Belongs to the disease resistance TIR-NB-LRR family. {ECO:0000305}.

Sequence caution: Sequence=BAB10247.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At5g45260 and At5g45270.; Evidence={ECO:0000305}; Sequence=BAB10248.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At5g45260 and At5g45270.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Arabidopsis thaliana (Mouse-ear cress).
Taxonomy:		Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.



Function:		Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. Acts also as a disease resistance protein involved in resistance to fungal and bacterial pathogens, including R.solanacearum, P.syringae pv. tomato and C.higginsianum. Heterodimerization with RPS4 is required to form a functional complex to recognize AvrRps4 and PopP2 (PubMed:24744375). Contributes to temperature-conditioned RPS4 auto- immunity (PubMed:24146667). {ECO:0000269\|PubMed:10571887, ECO:0000269\|PubMed:11842188, ECO:0000269\|PubMed:19519800, ECO:0000269\|PubMed:24146667, ECO:0000269\|PubMed:24744375, ECO:0000305}.


Subunit:		Interacts with PopP2, a R.solanacearum type III effector (PubMed:12788974). Interacts with RPS4 (PubMed:24744375). {ECO:0000269\|PubMed:12788974, ECO:0000269\|PubMed:24744375}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:12788974}. Cytoplasm {ECO:0000305\|PubMed:12788974}. Note=The nuclear localization is only detected upon interaction with PopP2. {ECO:0000269\|PubMed:12788974}.
Domain:		The TIR does not cause cell death, but can suppress RPS4 TIR domain-induced cell death (PubMed:24744375). The TIR domain is involved in homo- and heterodimerization, but other domains also contribute to the interaction (PubMed:24744375). {ECO:0000269\|PubMed:24744375}.
Miscellaneous:		Ecotypes susceptible to C.higginsianum or R.solanacearum, such as cv. Columbia, contain a protein with a premature stop codon, while the longer allele found in cv. Nd-1, cv. Wassilewskija or cv. RLD confers resistance. {ECO:0000269\|PubMed:19519800}.
Miscellaneous:		[Isoform 2]: May be due to intron retention. {ECO:0000305}.
Similarity:		Belongs to the disease resistance TIR-NB-LRR family. {ECO:0000305}.
Sequence caution:		Sequence=BAB10247.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At5g45260 and At5g45270.; Evidence={ECO:0000305}; Sequence=BAB10248.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At5g45260 and At5g45270.; Evidence={ECO:0000305};