UniProt functional annotation for Q71V39



	UniProt functional annotation for Q71V39

UniProt code: Q71V39.

Organism: Oryctolagus cuniculus (Rabbit).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.

Function: This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.

Subunit: Monomer. {ECO:0000250}.

Subcellular location: Nucleus {ECO:0000269|PubMed:9518480}.

Tissue specificity: Expressed in skeletal muscle, heart, brain and aorta. Not expressed in liver, kidney, spleen and lung.

Ptm: Methylated (PubMed:9518480). Trimethylated at Lys-165 by EEF1AKMT3. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs (By similarity). Trimethylated at the N-terminus and dimethylated at Lys-55 by EEF1AKNMT (By similarity). {ECO:0000250|UniProtKB:Q05639, ECO:0000269|PubMed:9518480}.

Similarity: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Oryctolagus cuniculus (Rabbit).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.



Function:		This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.


Subunit:		Monomer. {ECO:0000250}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:9518480}.
Tissue specificity:		Expressed in skeletal muscle, heart, brain and aorta. Not expressed in liver, kidney, spleen and lung.
Ptm:		Methylated (PubMed:9518480). Trimethylated at Lys-165 by EEF1AKMT3. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs (By similarity). Trimethylated at the N-terminus and dimethylated at Lys-55 by EEF1AKNMT (By similarity). {ECO:0000250\|UniProtKB:Q05639, ECO:0000269\|PubMed:9518480}.
Similarity:		Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. {ECO:0000305}.