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UniProt functional annotation for Q9BXH1 | ||
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| UniProt code: Q9BXH1. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338). {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}. |
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| Subunit: | |
Interacts with MCL1 and BCL2A1 (By similarity). Interacts (via BH3 domain) with BCL2 (PubMed:11463391). Interacts with BCL2L1/BCL-XL (PubMed:23340338). Interacts (via BH3 domain) with NOL3/ARC (via CARD domain); this interaction prevents BBC3 association with BCL2 and results in CASP8 activation (By similarity). {ECO:0000250|UniProtKB:Q80ZG6, ECO:0000250|UniProtKB:Q99ML1, ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}. |
| Subcellular location: | |
Mitochondrion {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:11463392, ECO:0000269|PubMed:11572983}. Note=Localized to the mitochondria in order to induce cytochrome c release. |
| Tissue specificity: | |
Ubiquitously expressed. {ECO:0000269|PubMed:11463391}. |
| Induction: | |
Up-regulated by TP53 (PubMed:11463392). Up-regulated by DNA damage, glucocorticoid treatment, growth factor deprivation and TP53 (PubMed:11572983). Up-regulated by ER stress in a DDIT3/CHOP-dependent manner (PubMed:22761832). {ECO:0000269|PubMed:11463392, ECO:0000269|PubMed:11572983, ECO:0000269|PubMed:22761832}. |
| Domain: | |
The BH3 motif is intrinsically disordered. {ECO:0000269|PubMed:23340338}. |
| Similarity: | |
Belongs to the Bcl-2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.