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UniProt functional annotation for Q9I700 | ||
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| UniProt code: Q9I700. |
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| Organism: | |
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. |
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| Function: | |
Involved in the degradation of beta-alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L- alanine and 3-oxopropanoate. It can also accept both 4-aminobutyrate and (S)-alpha-methylbenzylamine (MBA) as amino-group donors in the presence of pyruvate as an amine acceptor. {ECO:0000269|PubMed:21622750, ECO:0000269|PubMed:23519665}. |
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| Catalytic activity: | |
Reaction=3-oxopropanoate + L-alanine = beta-alanine + pyruvate; Xref=Rhea:RHEA:14077, ChEBI:CHEBI:15361, ChEBI:CHEBI:33190, ChEBI:CHEBI:57966, ChEBI:CHEBI:57972; EC=2.6.1.18; |
| Cofactor: | |
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:23519665, ECO:0000269|Ref.4}; |
| Activity regulation: | |
Inhibited by gabaculine (5-amino-1,3- cyclohexadienylcarboxylic acid). {ECO:0000269|PubMed:23519665}. |
| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:23519665, ECO:0000269|Ref.4}. |
| Induction: | |
Activated by BauR. {ECO:0000269|PubMed:21622750}. |
| Disruption phenotype: | |
Cells lacking this gene grow normally on putrescine, cadaverine, and GABA, but growth on beta-alanine is completely abolished. {ECO:0000269|PubMed:21622750}. |
| Similarity: | |
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.