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PDBsum entry 4b7e
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Oxidoreductase/peptide
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PDB id
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4b7e
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References listed in PDB file
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Key reference
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Title
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Substrate selectivity analyses of factor inhibiting hypoxia-Inducible factor.
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Authors
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M.Yang,
A.P.Hardy,
R.Chowdhury,
N.D.Loik,
J.S.Scotti,
J.S.Mccullagh,
T.D.Claridge,
M.A.Mcdonough,
W.Ge,
C.J.Schofield.
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Ref.
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Angew Chem Int Ed Engl, 2013,
52,
1700-1704.
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PubMed id
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Abstract
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Substrate specificity: Biochemical and crystallographic analyses reveal the
hypoxia-inducible factor hydroxylase (FIH) as being promiscuous with respect to
the residues that it can hydroxylate in β-position, which in addition to Asn,
Asp, and His include Leu and Ser residues. The Ser substrate is oxidized to an
epimeric β-geminal diol product.
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