UniProt functional annotation for Q2M3X8



	UniProt functional annotation for Q2M3X8

UniProt code: Q2M3X8.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization (PubMed:30256902). {ECO:0000250, ECO:0000269|PubMed:22976292, ECO:0000269|PubMed:23041370, ECO:0000269|PubMed:30256902}.

Subunit: Interacts (via RPEL repeats) with ACTA1 and PPP1CA; ACTA1 and PPP1CA compete for the same binding site. {ECO:0000269|PubMed:22976292, ECO:0000269|PubMed:23041370}.

Subcellular location: Cytoplasm. Cell junction, synapse {ECO:0000250}. Nucleus. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import. {ECO:0000250}.

Domain: Binds three actin monomers via the three C-terminal RPEL repeats. {ECO:0000269|PubMed:23041370}.

Disruption phenotype: PHACTR1 knockdown results in migration defects of cortical neurons. Neurons do not migrate to layers II-IV of the cortical plate but remain in the lower part and the intermediate zone. {ECO:0000269|PubMed:30256902}.

Similarity: Belongs to the phosphatase and actin regulator family. {ECO:0000305}.

Sequence caution: Sequence=AAH48407.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH61691.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC33272.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization (PubMed:30256902). {ECO:0000250, ECO:0000269\|PubMed:22976292, ECO:0000269\|PubMed:23041370, ECO:0000269\|PubMed:30256902}.


Subunit:		Interacts (via RPEL repeats) with ACTA1 and PPP1CA; ACTA1 and PPP1CA compete for the same binding site. {ECO:0000269\|PubMed:22976292, ECO:0000269\|PubMed:23041370}.
Subcellular location:		Cytoplasm. Cell junction, synapse {ECO:0000250}. Nucleus. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import. {ECO:0000250}.
Domain:		Binds three actin monomers via the three C-terminal RPEL repeats. {ECO:0000269\|PubMed:23041370}.
Disruption phenotype:		PHACTR1 knockdown results in migration defects of cortical neurons. Neurons do not migrate to layers II-IV of the cortical plate but remain in the lower part and the intermediate zone. {ECO:0000269\|PubMed:30256902}.
Similarity:		Belongs to the phosphatase and actin regulator family. {ECO:0000305}.
Sequence caution:		Sequence=AAH48407.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH61691.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC33272.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};