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UniProt functional annotation for Q53H82 | ||
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| UniProt code: Q53H82. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Endoribonuclease; cleaves preferentially 3' to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double- stranded RNA or DNA. Required for normal mitochondrial function and cell viability. {ECO:0000269|PubMed:26826708}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:26826708}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000269|PubMed:26826708}; |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:26826708}. |
| Subcellular location: | |
Mitochondrion matrix {ECO:0000269|PubMed:26826708}. |
| Miscellaneous: | |
RNAi-mediated down-regulation results in rapid cell death. The reason for this is not clear; there are only minor changes in mitochondrial mRNA levels. {ECO:0000269|PubMed:26826708}. |
| Similarity: | |
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.