UniProt functional annotation for P46597



	UniProt functional annotation for P46597

UniProt code: P46597.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Isoform 1 catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. {ECO:0000269|PubMed:22775292}.

Catalytic activity: Reaction=N-acetylserotonin + S-adenosyl-L-methionine = H(+) + melatonin + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:15573, ChEBI:CHEBI:15378, ChEBI:CHEBI:16796, ChEBI:CHEBI:17697, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.4; Evidence={ECO:0000269|PubMed:22775292};

Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.

Subunit: Homodimer. {ECO:0000269|PubMed:22775292}.

Tissue specificity: Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683). {ECO:0000269|PubMed:22775292, ECO:0000269|PubMed:7989373, ECO:0000269|PubMed:8574683}.

Induction: By all-trans-, 9-cis- and 13-cis-retinoic acid and by serum treatment, following starvation, in the retinoblastoma cell line Y79. {ECO:0000269|PubMed:8752109, ECO:0000269|PubMed:8842389}.

Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Miscellaneous: [Isoform 3]: Includes part of a LINE-1 element. {ECO:0000305}.

Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. {ECO:0000255|PROSITE-ProRule:PRU01020}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Isoform 1 catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. {ECO:0000269\|PubMed:22775292}.


Catalytic activity:		Reaction=N-acetylserotonin + S-adenosyl-L-methionine = H(+) + melatonin + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:15573, ChEBI:CHEBI:15378, ChEBI:CHEBI:16796, ChEBI:CHEBI:17697, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.4; Evidence={ECO:0000269\|PubMed:22775292};
Pathway:		Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
Subunit:		Homodimer. {ECO:0000269\|PubMed:22775292}.
Tissue specificity:		Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683). {ECO:0000269\|PubMed:22775292, ECO:0000269\|PubMed:7989373, ECO:0000269\|PubMed:8574683}.
Induction:		By all-trans-, 9-cis- and 13-cis-retinoic acid and by serum treatment, following starvation, in the retinoblastoma cell line Y79. {ECO:0000269\|PubMed:8752109, ECO:0000269\|PubMed:8842389}.
Miscellaneous:		The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
Miscellaneous:		[Isoform 3]: Includes part of a LINE-1 element. {ECO:0000305}.
Similarity:		Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. {ECO:0000255\|PROSITE-ProRule:PRU01020}.