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UniProt functional annotation for Q9I2U6 | ||
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| UniProt code: Q9I2U6. |
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| Organism: | |
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. |
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| Function: | |
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. {ECO:0000255|HAMAP-Rule:MF_01576, ECO:0000269|PubMed:22558288}. |
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| Catalytic activity: | |
Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH; Xref=Rhea:RHEA:22812, ChEBI:CHEBI:15636, ChEBI:CHEBI:57455, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.5; Evidence={ECO:0000255|HAMAP- Rule:MF_01576, ECO:0000269|PubMed:22558288}; |
| Catalytic activity: | |
Reaction=5,10-methenyltetrahydrofolate + H2O = (6S)-10- formyltetrahydrofolate + H(+); Xref=Rhea:RHEA:23700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57454, ChEBI:CHEBI:57455; EC=3.5.4.9; Evidence={ECO:0000255|HAMAP- Rule:MF_01576, ECO:0000269|PubMed:22558288}; |
| Pathway: | |
One-carbon metabolism; tetrahydrofolate interconversion. {ECO:0000255|HAMAP-Rule:MF_01576}. |
| Subunit: | |
Homodimer. {ECO:0000255|HAMAP-Rule:MF_01576, ECO:0000269|PubMed:22558288}. |
| Similarity: | |
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. {ECO:0000255|HAMAP-Rule:MF_01576}. |
Annotations taken from UniProtKB at the EBI.