PDBsum entry 4amj

Membrane protein

PDB id

4amj

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Contents

			Protein chains

					287 a.a.

			Ligands

					CVD ×2


					2CV ×12

			Metals

					_NA ×2

			Waters ×101

PDB id:

4amj

Links

Name:

Membrane protein

Title:

Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist carvedilol

Structure:

Beta-1 adrenergic receptor. Chain: a, b. Fragment: residues 33-243,272-368. Synonym: beta-1 adrenoreceptor, beta-1 adrenoceptor, beta-t. Engineered: yes. Mutation: yes

Source:

Meleagris gallopavo. Turkey. Organism_taxid: 9103. Cell: erythrocyte. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.

Resolution:

2.30Å

R-factor:

0.204

R-free:

0.240

Authors:

T.Warne,P.C.Edwards,A.G.Leslie,C.G.Tate

Key ref:

T.Warne et al. (2012). Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol. Structure, 20, 841-849. PubMed id: 22579251

Date:

12-Mar-12

Release date:

23-May-12

PROCHECK

	Headers

	References

Protein chains

P07700 (ADRB1_MELGA) - Beta-1 adrenergic receptor from Meleagris gallopavo

Seq: Struc:					483 a.a. 287 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

	Structure 20:841-849 (2012)
PubMed id: 22579251

Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol.
T.Warne, P.C.Edwards, A.G.Leslie, C.G.Tate.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23407534

A.J.Venkatakrishnan, X.Deupi, G.Lebon, C.G.Tate, G.F.Schertler, and M.M.Babu (2013).
Molecular signatures of G-protein-coupled receptors.

Nature, 494, 185-194.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.