UniProt functional annotation for Q08024



	UniProt functional annotation for Q08024

UniProt code: Q08024.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'- TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T- cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). {ECO:0000269|PubMed:18258917, ECO:0000305|PubMed:11257229, ECO:0000305|PubMed:8386878, ECO:0000305|PubMed:8497254}.

Subunit: Heterodimer with RUNX1, RUNX2 and RUNX3 (Probable). Interacts with COPRS. Found in a complex with PRMT5 and RUNX1 (PubMed:22193545). {ECO:0000269|PubMed:22193545, ECO:0000305|PubMed:11257229}.

Subcellular location: Nucleus {ECO:0000305}.

Tissue specificity: Expressed in all tissues tested. Highest level in thymus, but also abundantly expressed in muscle, lung and brain.

Miscellaneous: [Isoform 2]: Major isoform. {ECO:0000305}.

Miscellaneous: [Isoform 3]: Does not dimerize with the alpha subunit. {ECO:0000305}.

Miscellaneous: [Isoform 4]: Does not dimerize with the alpha subunit. {ECO:0000305}.

Similarity: Belongs to the CBF-beta family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'- TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T- cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). {ECO:0000269\|PubMed:18258917, ECO:0000305\|PubMed:11257229, ECO:0000305\|PubMed:8386878, ECO:0000305\|PubMed:8497254}.


Subunit:		Heterodimer with RUNX1, RUNX2 and RUNX3 (Probable). Interacts with COPRS. Found in a complex with PRMT5 and RUNX1 (PubMed:22193545). {ECO:0000269\|PubMed:22193545, ECO:0000305\|PubMed:11257229}.
Subcellular location:		Nucleus {ECO:0000305}.
Tissue specificity:		Expressed in all tissues tested. Highest level in thymus, but also abundantly expressed in muscle, lung and brain.
Miscellaneous:		[Isoform 2]: Major isoform. {ECO:0000305}.
Miscellaneous:		[Isoform 3]: Does not dimerize with the alpha subunit. {ECO:0000305}.
Miscellaneous:		[Isoform 4]: Does not dimerize with the alpha subunit. {ECO:0000305}.
Similarity:		Belongs to the CBF-beta family. {ECO:0000305}.