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PDBsum entry 3vtt
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Viral protein, structural protein
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PDB id
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3vtt
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References listed in PDB file
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Key reference
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Title
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High resolution crystal structure of dengue-3 envelope protein domain III suggests possible molecular mechanisms for serospecific antibody recognition.
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Authors
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M.Elahi,
M.M.Islam,
K.Noguchi,
M.Yohda,
Y.Kuroda.
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Ref.
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Proteins, 2013,
81,
1090-1095.
[DOI no: ]
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PubMed id
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Abstract
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Dengue viruses are classified into four serotypes. Here, we report a 1.7 Å
crystal structure of a recombinant dengue-3 envelope protein domain III (ED3),
which contains most of the putative epitopes. Although the fold was well
conserved, we found that a local backbone deformation in the first β-strand,
which contains the putative epitope-1, occurred upon domain isolation.
Furthermore, a comparison with dengue-2 ED3 indicated a large structural change
by as much as 4.0 Å at Asp(662) , located in epitope-2. These minute structural
and surface properties changes observed in the high resolution ED3 structure
represent potential determinants for serospecificity and epitope recognition by
antibodies. © 2012 Wiley Periodicals, Inc.
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