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UniProt functional annotation for O44074 | ||
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| UniProt code: O44074. |
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| Organism: | |
Ascaris suum (Pig roundworm) (Ascaris lumbricoides). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris. |
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| Function: | |
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). {ECO:0000256|ARBA:ARBA00002787, ECO:0000256|RuleBase:RU361237}. |
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| Catalytic activity: | |
Reaction=a quinone + succinate = a quinol + fumarate; Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806, ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; Evidence={ECO:0000256|RuleBase:RU361237}; |
| Catalytic activity: | |
Reaction=a quinone + succinate = a quinol + fumarate; Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806, ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; EC=1.3.5.1; Evidence={ECO:0000256|ARBA:ARBA00000030}; |
| Cofactor: | |
Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000256|ARBA:ARBA00001939}; |
| Cofactor: | |
Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000256|RuleBase:RU361237}; Note=Binds 1 [2Fe-2S] cluster. {ECO:0000256|RuleBase:RU361237}; |
| Cofactor: | |
Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; Evidence={ECO:0000256|ARBA:ARBA00001927}; |
| Cofactor: | |
Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; Evidence={ECO:0000256|RuleBase:RU361237}; Note=Binds 1 [3Fe-4S] cluster. {ECO:0000256|RuleBase:RU361237}; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000256|ARBA:ARBA00001966}; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000256|RuleBase:RU361237}; Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|RuleBase:RU361237}; |
| Pathway: | |
Carbohydrate metabolism. {ECO:0000256|ARBA:ARBA00005007}. |
| Pathway: | |
Carbohydrate metabolism; tricarboxylic acid cycle. {ECO:0000256|ARBA:ARBA00005163}. |
| Pathway: | |
Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. {ECO:0000256|ARBA:ARBA00004788, ECO:0000256|RuleBase:RU361237}. |
| Subcellular location: | |
Mitochondrion inner membrane {ECO:0000256|RuleBase:RU361237}; Peripheral membrane protein {ECO:0000256|RuleBase:RU361237}; Matrix side {ECO:0000256|RuleBase:RU361237}. |
| Similarity: | |
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. {ECO:0000256|ARBA:ARBA00009433, ECO:0000256|RuleBase:RU361237}. |
Annotations taken from UniProtKB at the EBI.