UniProt functional annotation for Q9JHF9



	UniProt functional annotation for Q9JHF9

UniProt code: Q9JHF9.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Binds bacterial lipopolysaccharide (LPS) (PubMed:22532668). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10725698). {ECO:0000250|UniProtKB:Q9Y6Y9, ECO:0000269|PubMed:10725698, ECO:0000269|PubMed:20133493, ECO:0000269|PubMed:24380872}.

Subunit: Heterogeneous homomer formed from homodimers; disulfide-linked (By similarity). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:10725698, PubMed:20133493, PubMed:24380872). Binds to the extracellular domain of TLR4 (PubMed:10725698, PubMed:20133493, PubMed:24380872, PubMed:17803912, PubMed:22532668). Binds to the extracellular domain of TLR2 (By similarity). Ligand binding induces interaction with TLR4 and oligomerization of the complex (PubMed:20133493, PubMed:24380872, PubMed:22532668). {ECO:0000250|UniProtKB:Q9Y6Y9, ECO:0000269|PubMed:10725698, ECO:0000269|PubMed:17803912, ECO:0000269|PubMed:20133493, ECO:0000269|PubMed:22532668, ECO:0000269|PubMed:24380872}.

Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:10725698, ECO:0000269|PubMed:20133493, ECO:0000305|PubMed:24380872}. Secreted {ECO:0000269|PubMed:10891475}. Note=Retained in the extracellular space at the cell surface by interaction with TLR4. {ECO:0000269|PubMed:10725698, ECO:0000269|PubMed:20133493, ECO:0000305|PubMed:24380872}.

Tissue specificity: Highly expressed in spleen, bone marrow, thymus, liver, kidney, ovary and decidua. Detected at lower levels in testis, small intestine and skin. {ECO:0000269|PubMed:10891475}.

Ptm: N-glycosylated. {ECO:0000269|PubMed:17803912}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Binds bacterial lipopolysaccharide (LPS) (PubMed:22532668). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10725698). {ECO:0000250\|UniProtKB:Q9Y6Y9, ECO:0000269\|PubMed:10725698, ECO:0000269\|PubMed:20133493, ECO:0000269\|PubMed:24380872}.


Subunit:		Heterogeneous homomer formed from homodimers; disulfide-linked (By similarity). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:10725698, PubMed:20133493, PubMed:24380872). Binds to the extracellular domain of TLR4 (PubMed:10725698, PubMed:20133493, PubMed:24380872, PubMed:17803912, PubMed:22532668). Binds to the extracellular domain of TLR2 (By similarity). Ligand binding induces interaction with TLR4 and oligomerization of the complex (PubMed:20133493, PubMed:24380872, PubMed:22532668). {ECO:0000250\|UniProtKB:Q9Y6Y9, ECO:0000269\|PubMed:10725698, ECO:0000269\|PubMed:17803912, ECO:0000269\|PubMed:20133493, ECO:0000269\|PubMed:22532668, ECO:0000269\|PubMed:24380872}.
Subcellular location:		Secreted, extracellular space {ECO:0000269\|PubMed:10725698, ECO:0000269\|PubMed:20133493, ECO:0000305\|PubMed:24380872}. Secreted {ECO:0000269\|PubMed:10891475}. Note=Retained in the extracellular space at the cell surface by interaction with TLR4. {ECO:0000269\|PubMed:10725698, ECO:0000269\|PubMed:20133493, ECO:0000305\|PubMed:24380872}.
Tissue specificity:		Highly expressed in spleen, bone marrow, thymus, liver, kidney, ovary and decidua. Detected at lower levels in testis, small intestine and skin. {ECO:0000269\|PubMed:10891475}.
Ptm:		N-glycosylated. {ECO:0000269\|PubMed:17803912}.