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UniProt functional annotation for Q99T05 | ||
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| UniProt code: Q99T05. |
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| Organism: | |
Staphylococcus aureus (strain Mu50 / ATCC 700699). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
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| Function: | |
Peptidoglycan polymerase that catalyzes glycan chain elongation using lipid-linked disaccharide-pentapeptide as the substrate. {ECO:0000255|HAMAP-Rule:MF_01434}. |
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| Catalytic activity: | |
Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc- (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+); Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603, ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033, ChEBI:CHEBI:78435; EC=2.4.1.129; Evidence={ECO:0000255|HAMAP- Rule:MF_01434}; |
| Pathway: | |
Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01434}. |
| Subcellular location: | |
Cell membrane {ECO:0000255|HAMAP-Rule:MF_01434}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01434}. |
| Similarity: | |
Belongs to the glycosyltransferase 51 family. {ECO:0000255|HAMAP-Rule:MF_01434}. |
Annotations taken from UniProtKB at the EBI.