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UniProt functional annotation for Q28142 | ||
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| UniProt code: Q28142. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity). {ECO:0000250}. |
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| Subunit: | |
The cytoplasmic C-terminal region binds to CASK. Binds NLGN1, NLGN2 and NLGN3, DAG1 (alpha-dystroglycan) and alpha-latrotoxin. Binding to neuroligins is calcium-dependent, and the binding preference ranks as follow: NLGN1 > NLGN4 >> NLGN3 > NLGN2 (By similarity). Interacts CBLN2 and more weakly with CBLN4 (By similarity). Interacts with CBLN1; interaction is CBLN1 hexamer form-dependent; CBLN1-binding is calcium-independent; isoform 1b does not interact with CBLN1 (By similarity). {ECO:0000250|UniProtKB:P0DI97, ECO:0000250|UniProtKB:P58400, ECO:0000250|UniProtKB:Q63373}. |
| Subcellular location: | |
Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:Q63373}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q63373}. |
| Ptm: | |
Highly O-glycosylated and minor N-glycosylated. {ECO:0000250}. |
| Similarity: | |
Belongs to the neurexin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.