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PDBsum entry 3vfd
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protein ligands links
Hydrolase PDB id
3vfd

 

 

 

 

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JSmol PyMol  
Contents
Protein chain
266 a.a.
Ligands
SO4
PDB id:
3vfd
Name: Hydrolase
Title: Human spastin aaa domain
Structure: Spastin. Chain: a. Fragment: aaa domain. Synonym: spastic paraplegia 4 protein. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adpsp, fsp2, kiaa1083, spast, spg4. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Resolution:
3.30Å     R-factor:   0.214     R-free:   0.275
Authors: J.L.Taylor,S.R.White,B.Lauring,F.J.Kull
Key ref: J.L.Taylor et al. (2012). Crystal structure of the human spastin AAA domain. J Struct Biol, 179, 133-137. PubMed id: 22446388
Date:
09-Jan-12     Release date:   30-May-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9UBP0  (SPAST_HUMAN) -  Spastin from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		616 a.a.
266 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.5.6.1.1  - microtubule-severing ATPase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers
n ATP
 + n H2O
 + microtubule
 = n ADP
 + n phosphate
 + (n+1) alpha/beta tubulin heterodimers
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
J Struct Biol 179:133-137 (2012)
PubMed id: 22446388  
 
 
Crystal structure of the human spastin AAA domain.
J.L.Taylor, S.R.White, B.Lauring, F.J.Kull.
 
  ABSTRACT  
 
No abstract given.

 

 

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