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UniProt functional annotation for Q6SW59 | ||
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| UniProt code: Q6SW59. |
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| Organism: | |
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus. |
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| Function: | |
Counteracts the host antiviral immune response by preventing IRF3 from entering the nucleus once activated and phosphorylated. Participates also in the transactivation of viral major immediate-early genes by recruiting host IFI16 to their promoters. |
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| Subunit: | |
Interacts with host NCL/nucleolin. Interacts with host IFI16. |
| Subcellular location: | |
Virion tegument {ECO:0000305}. Host nucleus {ECO:0000250|UniProtKB:P06725}. Host cytoplasm {ECO:0000250|UniProtKB:P06725}. Note=As part of the incoming virion, pp65 is targeted to the nucleus immediately after infection. The newly synthesized pp65 is observed in the nucleus until some time after 48 hours postinfection. Thereafter, pp65 is probably exported and accumulates in the cytoplasm. Also found in dense bodies. {ECO:0000250|UniProtKB:P06725}. |
| Ptm: | |
Phosphorylation may play a role in the localization of the protein. |
| Similarity: | |
Belongs to the herpesviridae pp65 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.