UniProt functional annotation for Q9F1Y6



	UniProt functional annotation for Q9F1Y6

UniProt code: Q9F1Y6.

Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).

Taxonomy: Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.

Function: Catalyzes the cyclization of 2-methylgeranyl diphosphate (2- MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate. Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%). {ECO:0000269|PubMed:18563898}.

Catalytic activity: Reaction=(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate; Xref=Rhea:RHEA:32571, ChEBI:CHEBI:15377, ChEBI:CHEBI:33019, ChEBI:CHEBI:61984, ChEBI:CHEBI:61987; EC=4.2.3.118; Evidence={ECO:0000269|PubMed:18563898};

Cofactor: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305|PubMed:18563898};

Miscellaneous: 2-MIB is a volatile organic compound that has an unusually low odor threshold. Together with geosmin, methylisoborneol is responsible for the characteristic smell of moist soil as well as unpleasant taste and odor episodes associated with public water supplies and contamination of various foodstuffs, including fish, wine, and beer.

Similarity: Belongs to the terpene synthase family. 2-methylisoborneol synthase subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
Taxonomy:		Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.



Function:		Catalyzes the cyclization of 2-methylgeranyl diphosphate (2- MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate. Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%). {ECO:0000269\|PubMed:18563898}.


Catalytic activity:		Reaction=(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate; Xref=Rhea:RHEA:32571, ChEBI:CHEBI:15377, ChEBI:CHEBI:33019, ChEBI:CHEBI:61984, ChEBI:CHEBI:61987; EC=4.2.3.118; Evidence={ECO:0000269\|PubMed:18563898};
Cofactor:		Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305\|PubMed:18563898};
Miscellaneous:		2-MIB is a volatile organic compound that has an unusually low odor threshold. Together with geosmin, methylisoborneol is responsible for the characteristic smell of moist soil as well as unpleasant taste and odor episodes associated with public water supplies and contamination of various foodstuffs, including fish, wine, and beer.
Similarity:		Belongs to the terpene synthase family. 2-methylisoborneol synthase subfamily. {ECO:0000305}.