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UniProt functional annotation for Q2T7H5 | ||
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| UniProt code: Q2T7H5. |
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| Organism: | |
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264). |
| Taxonomy: | |
Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; pseudomallei group. |
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| Function: | |
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. {ECO:0000256|ARBA:ARBA00002492, ECO:0000256|HAMAP- Rule:MF_02121}. |
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| Catalytic activity: | |
Reaction=L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho- L-aspartate + H(+) + NADPH; Xref=Rhea:RHEA:24284, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57535, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:537519; EC=1.2.1.11; Evidence={ECO:0000256|ARBA:ARBA00001636, ECO:0000256|HAMAP- Rule:MF_02121}; |
| Pathway: | |
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4. {ECO:0000256|ARBA:ARBA00005076, ECO:0000256|HAMAP-Rule:MF_02121}. |
| Pathway: | |
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3. {ECO:0000256|ARBA:ARBA00005021, ECO:0000256|HAMAP-Rule:MF_02121}. |
| Pathway: | |
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5. {ECO:0000256|ARBA:ARBA00005097, ECO:0000256|HAMAP-Rule:MF_02121}. |
| Subunit: | |
Homodimer. {ECO:0000256|ARBA:ARBA00011738, ECO:0000256|HAMAP- Rule:MF_02121}. |
| Similarity: | |
Belongs to the aspartate-semialdehyde dehydrogenase family. {ECO:0000256|ARBA:ARBA00010584, ECO:0000256|HAMAP-Rule:MF_02121}. |
Annotations taken from UniProtKB at the EBI.