PDBsum entry 3ue4

Transferase/transferase inhibitor

PDB id

3ue4

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Contents

			Protein chain

					270 a.a.

			Ligands

					DB8 ×2

			Waters ×152

PDB id:

3ue4

Links

Name:

Transferase/transferase inhibitor

Title:

Structural and spectroscopic analysis of the kinase inhibitor bosutinib binding to the abl tyrosine kinase domain

Structure:

Tyrosine-protein kinase abl1. Chain: a, b. Synonym: abelson murine leukemia viral oncogene homolog 1, abelson tyrosine-protein kinase 1, proto-oncogenE C-abl, p150. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.42Å

R-factor:

0.192

R-free:

0.249

Authors:

S.G.Boxer,N.M.Levinson

Key ref:

N.M.Levinson and S.G.Boxer (2012). Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain. Plos One, 7, e29828. PubMed id: 22493660

Date:

28-Oct-11

Release date:

18-Apr-12

PROCHECK

	Headers

	References

Protein chains

P00519 (ABL1_HUMAN) - Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: Struc:

Seq: Struc:

Seq: Struc:					1130 a.a. 270 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.2.7.10.2 - non-specific protein-tyrosine kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein]	+	ATP	=	O-phospho-L-tyrosyl-[protein]	+	ADP	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

	Plos One 7:e29828 (2012)
PubMed id: 22493660

Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain.
N.M.Levinson, S.G.Boxer.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22965154

J.Munoz, and R.Kurzrock (2012).
Targeted therapy in rare cancers-adopting the orphans.

Nat Rev Clin Oncol, 9, 631-642.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.