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UniProt functional annotation for P29372 | ||
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| UniProt code: P29372. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. |
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| Catalytic activity: | |
Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3- methylguanine, 7-methylguanine and 7-methyladenine.; EC=3.2.2.21; |
| Activity regulation: | |
Binding to SSBP1 in mitochondria inhibits glycosylase activity in the context of a single-stranded DNA (ssDNA), but not a double-stranded DNA (dsDNA) substrates. {ECO:0000269|PubMed:23290262}. |
| Subunit: | |
Binds MBD1. Binds SSBP1. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:23290262}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:23290262}. Nucleus {ECO:0000269|PubMed:23290262}. |
| Similarity: | |
Belongs to the DNA glycosylase MPG family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.