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PDBsum entry 3tid
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Immune system
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PDB id
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3tid
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References listed in PDB file
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Key reference
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Title
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Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-Mhc structural features recognized by cross-Reactive t cells.
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Authors
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Z.T.Shen,
T.T.Nguyen,
K.A.Daniels,
R.M.Welsh,
L.J.Stern.
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Ref.
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J Immunol, 2013,
191,
5139-5152.
[DOI no: ]
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PubMed id
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Abstract
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Closely related peptide epitopes can be recognized by the same T cells and
contribute to the immune response against pathogens encoding those epitopes, but
sometimes cross-reactive epitopes share little homology. The degree of
structural homology required for such disparate ligands to be recognized by
cross-reactive TCRs remains unclear. In this study, we examined the mechanistic
basis for cross-reactive T cell responses between epitopes from unrelated and
pathogenic viruses, lymphocytic choriomeningitis virus (LCMV) and vaccinia
virus. Our results show that the LCMV cross-reactive T cell response toward
vaccinia virus is dominated by a shared asparagine residue, together with other
shared structural elements conserved in the crystal structures of K(b)-VV-A11R
and K(b)-LCMV-gp34. Based on analysis of the crystal structures and the
specificity determinants for the cross-reactive T cell response, we were able to
manipulate the degree of cross-reactivity of the T cell response, and to predict
and generate a LCMV cross-reactive response toward a variant of a null
OVA-derived peptide. These results indicate that protective heterologous immune
responses can occur for disparate epitopes from unrelated viruses.
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