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UniProt functional annotation for B1YAL1 | ||
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| UniProt code: B1YAL1. |
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| Organism: | |
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta) (Thermoproteus neutrophilus). |
| Taxonomy: | |
Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae; Pyrobaculum. |
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| Function: | |
Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). {ECO:0000269|PubMed:20348906, ECO:0000269|PubMed:21983965}. |
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| Catalytic activity: | |
Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377, ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11; Evidence={ECO:0000269|PubMed:20348906, ECO:0000269|PubMed:21983965}; |
| Catalytic activity: | |
Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3- phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13; Evidence={ECO:0000269|PubMed:20348906, ECO:0000269|PubMed:21983965}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:21983965}; |
| Pathway: | |
Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000305|PubMed:20348906}. |
| Subunit: | |
Homooctamer; dimer of tetramers. {ECO:0000269|PubMed:21983965}. |
| Domain: | |
Consists of a single catalytic domain, but remodels its active- site architecture via a large structural change to exhibit dual activities. {ECO:0000269|PubMed:21983965}. |
| Similarity: | |
Belongs to the FBP aldolase/phosphatase family. {ECO:0000255|HAMAP-Rule:MF_02067, ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.