|
|
||
|
|
|
|
|
UniProt functional annotation for Q00194 | ||
|
|
|
|
|
|
||
| UniProt code: Q00194. |
|
||
| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
|
||
|
||
| Function: | |
Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. {ECO:0000269|PubMed:2481236}. |
|
||
| Subunit: | |
Forms a heterotetramer with CNGB1 in a 3:1 ratio (PubMed:21878911). May also form cyclic nucleotide-activated homotetrameric channels, that are efficiently activated by saturating cGMP, but poorly activated by saturating cAMP compared to the heterotetramer with CNGB1 (PubMed:21878911). {ECO:0000269|PubMed:21878911}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:1370452}; Multi-pass membrane protein {ECO:0000269|PubMed:1370452, ECO:0000269|PubMed:25963832}. |
| Tissue specificity: | |
Expressed in the retina, in rod cells (at protein level). {ECO:0000269|PubMed:1370452}. |
| Domain: | |
The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits. |
| Similarity: | |
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.