PDBsum entry 3spi

Metal transport

PDB id

3spi

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Contents

			Protein chain

					332 a.a.

			Ligands

					PIO

			Metals

					__K ×4

PDB id:

3spi

Links

Name:

Metal transport

Title:

Inward rectifier potassium channel kir2.2 in complex with pip2

Structure:

Inward-rectifier k+ channel kir2.2. Chain: a. Synonym: inward rectifier potassium channel 2.2. Engineered: yes

Source:

Gallus gallus. Chicken. Organism_taxid: 9031. Gene: kir2.2. Expressed in: pichia pastoris. Expression_system_taxid: 4922

Resolution:

3.31Å

R-factor:

0.237

R-free:

0.278

Authors:

S.B.Hansen,X.Tao,R.Mackinnon

Key ref:

S.B.Hansen et al. (2011). Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature, 477, 495-498. PubMed id: 21874019

Date:

01-Jul-11

Release date:

24-Aug-11

PROCHECK

	Headers

	References

Protein chain

F1NHE9 (KCJ12_CHICK) - ATP-sensitive inward rectifier potassium channel 12 from Gallus gallus

Seq: Struc:					429 a.a. 332 a.a.*

Key:

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

	Nature 477:495-498 (2011)
PubMed id: 21874019

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2.
S.B.Hansen, X.Tao, R.MacKinnon.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23201688

X.Shi, Y.Bi, W.Yang, X.Guo, Y.Jiang, C.Wan, L.Li, Y.Bai, J.Guo, Y.Wang, X.Chen, B.Wu, H.Sun, W.Liu, J.Wang, and C.Xu (2013).
Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids.

Nature, 493, 111-115.

22231399

V.N.Bavro, R.De Zorzi, M.R.Schmidt, J.R.Muniz, L.Zubcevic, M.S.Sansom, C.Vénien-Bryan, and S.J.Tucker (2012).
Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.

Nat Struct Mol Biol, 19, 158-163.

PDB code:

3zrs

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.