UniProt functional annotation for P53192



	UniProt functional annotation for P53192

UniProt code: P53192.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP- dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in mitochondrial distribution and morphology. {ECO:0000255|HAMAP- Rule:MF_03113, ECO:0000269|PubMed:11907266, ECO:0000269|PubMed:16269340, ECO:0000269|PubMed:18724936, ECO:0000269|PubMed:21719644, ECO:0000269|PubMed:21835666, ECO:0000269|PubMed:24392163}.

Subunit: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (PubMed:32910895). {ECO:0000255|HAMAP-Rule:MF_03113, ECO:0000269|PubMed:11805837, ECO:0000269|PubMed:16269340, ECO:0000269|PubMed:21719644, ECO:0000269|PubMed:21835666, ECO:0000269|PubMed:32910895}.

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane {ECO:0000269|PubMed:16823961}; Multi- pass membrane protein {ECO:0000269|PubMed:16823961}.

Miscellaneous: Present with 2250 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Similarity: Belongs to the WRB/GET1 family. {ECO:0000255|HAMAP- Rule:MF_03113}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP- dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in mitochondrial distribution and morphology. {ECO:0000255\|HAMAP- Rule:MF_03113, ECO:0000269\|PubMed:11907266, ECO:0000269\|PubMed:16269340, ECO:0000269\|PubMed:18724936, ECO:0000269\|PubMed:21719644, ECO:0000269\|PubMed:21835666, ECO:0000269\|PubMed:24392163}.


Subunit:		Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (PubMed:32910895). {ECO:0000255\|HAMAP-Rule:MF_03113, ECO:0000269\|PubMed:11805837, ECO:0000269\|PubMed:16269340, ECO:0000269\|PubMed:21719644, ECO:0000269\|PubMed:21835666, ECO:0000269\|PubMed:32910895}.
Subcellular location:		Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane {ECO:0000269\|PubMed:16823961}; Multi- pass membrane protein {ECO:0000269\|PubMed:16823961}.
Miscellaneous:		Present with 2250 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity:		Belongs to the WRB/GET1 family. {ECO:0000255\|HAMAP- Rule:MF_03113}.