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UniProt functional annotation for P01552 | ||
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| UniProt code: P01552. |
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| Organism: | |
Staphylococcus aureus. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
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| Function: | |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines (PubMed:2303780, PubMed:25015819). Causes also the intoxication staphylococcal food poisoning syndrome (By similarity). {ECO:0000250|UniProtKB:P34071, ECO:0000269|PubMed:2303780, ECO:0000269|PubMed:25015819}. |
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| Subunit: | |
Interacts with MHC class II molecules composed of alpha/HLA- DRA and beta/HLA-DRB1 chains (PubMed:8152483, PubMed:25015819). Interacts with T-cell receptor beta variable 19/TRBV19 (PubMed:9881971, PubMed:25015819). {ECO:0000269|PubMed:25015819, ECO:0000269|PubMed:8152483, ECO:0000269|PubMed:9881971}. |
| Subcellular location: | |
Secreted. |
| Miscellaneous: | |
Lacks the zinc-binding site found in other members of this family, such as staphylococcal enterotoxin A, C2 and D, thus it possesses only one MHC class II binding site. {ECO:0000305|PubMed:9514739}. |
| Similarity: | |
Belongs to the staphylococcal/streptococcal toxin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.